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Profiles on the subtestsof the Mattis Dementia Rating Scale (Connor et al., 1998)and on the California Verbal Learning Test (Hamiltonet al., 2004) have been moderately successful in distin-guishing the two diseases in autopsy-verified cases.

These cognitiveand functional measures as required now lead to expen-sive and long trials that may be inadequately poweredand add significant costs. In treatment-naive patients,therapy with 3 drugs is considered optimal.Addition of a fourth drug affords no additionalbenefit; may be tried in failed patients only. Riley T, Sontag E, Chen P, Levine A (2008) Transcriptional control of human p53-regulatedgenes.

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It is a neoplastic disorder of lymphocyte, usually involving the B lymphocytes (95%) and rarelyT lymphocytes (5%).